STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. IX. EFFECT OF PAMAQUINE ON THE BLOOD CELLS OF MAN 123

Abstract

Admn. of pamaquine results in methemoglobinemia which is roughly proportional to dosage. The effect is potentiated by concurrent quinacrine treatment. Some 5-10% of non-Caucasian patients given pamaquine develop acute hemolytic anemia on the 3d to 5th day of dosage. The incidence of hemolytic anemia among white patients given pamaquine is much lower. Admn. of 90 mg. of pamaquine for 14 days results in a significant reduction of mature neutro-philic granulocytes. Pamaquine in daily doses of 30 mg. does not have this effect unless quinacrine is also administered.