Recent advances in arginine metabolism: roles and regulation of the arginases
Open Access
- 13 July 2009
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 157 (6), 922-930
- https://doi.org/10.1111/j.1476-5381.2009.00278.x
Abstract
As arginine can serve as precursor to a wide range of compounds, including nitric oxide, creatine, urea, polyamines, proline, glutamate and agmatine, there is considerable interest in elucidating mechanisms underlying regulation of its metabolism. It is now becoming apparent that the two isoforms of arginase in mammals play key roles in regulation of most aspects of arginine metabolism in health and disease. In particular, work over the past several years has focused on the roles and regulation of the arginases in vascular disease, pulmonary disease, infectious disease, immune cell function and cancer. As most of these topics have been considered in recent review articles, this review will focus more closely on results of recent studies on expression of the arginases in endothelial and vascular smooth muscle cells, post-translational modulation of arginase activity and applications of arginase inhibitors in vivo.Keywords
This publication has 95 references indexed in Scilit:
- Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbuminToxicology and Applied Pharmacology, 2009
- The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteriesBritish Journal of Pharmacology, 2008
- Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogensNature Immunology, 2008
- Arginase blockade lessens endothelial dysfunction after thrombosisJournal of Vascular Surgery, 2008
- Cysteine–iron promotes arginase activity by driving the Fenton reactionBiochemical and Biophysical Research Communications, 2008
- Arginase blockade protects against hepatic damage in warm ischemia-reperfusionNitric Oxide, 2008
- Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectivesImmunological Reviews, 2008
- Uric Acid as a Pathogenic Factor in PreeclampsiaPlacenta, 2008
- ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR FUNCTIONClinical and Experimental Pharmacology and Physiology, 2007
- Regulation of immune responses by L-arginine metabolismNature Reviews Immunology, 2005