Novel genes influencing the expression of the yellow locus and mdg4 (gypsy) in Drosophila melanogaster
- 1 December 1989
- journal article
- research article
- Published by Springer Science and Business Media LLC in Molecular Genetics and Genomics
- Vol. 220 (1), 121-126
- https://doi.org/10.1007/bf00260865
Abstract
We used a system with a mobilized Stalker transposable element, sometimes in combination with P-M hybrid dysgenesis, in the search for new mutations interfering with the y 2 mutation induced by mdg4 (gypsy) insertion into the yellow locus. A novel gene, modifier of mdg4, was detected in chromosome 3. The mutation mod(mdg4) either enhanced or suppressed phenotypic changes in different mutations induced by mdg4 insertions. Thus, mod(mdg4) seems to be involved in the control of mdg4 expression. Six other loci designated as enhancers of yellow were also detected. The e(y) n (with n from 1–6) mutations enhanced the expression of several y mutations induced by different insertions into the yellow locus. The major change is a damage of bristle and hair pigmentation which is not suppressed by su(Hw) mutations. On the other hand, e(y) n alleles do not interact with mdg4 induced mutations in other loci. All e(y) n genes are located in different regions of the X chromosome. One may speculate that e(y) n genes are involved in trans-regulation of the yellow locus and possibly of some other loci.This publication has 21 references indexed in Scilit:
- Mobile genetic elements in Drosophila melanogaster (recent experiments)Genome, 1989
- Separate regulatory elements are responsible for the complex pattern of tissue-specific and developmental transcription of the yellow locus in Drosophila melanogaster.Genes & Development, 1987
- Regulation of Inducible and Tissue-Specific Gene ExpressionScience, 1987
- Interactions among the gypsy transposable element and the yellow and the suppressor of hairy-wing loci in Drosophila melanogaster.Molecular and Cellular Biology, 1986
- Genetic Analysis of MorphogenesisPublished by Springer Science and Business Media LLC ,1986
- Molecular analysis of the yellow gene (y) region of Drosophila melanogaster.Proceedings of the National Academy of Sciences, 1985
- Molecular genetics of the achaete-scute gene complex of D. melanogasterCell, 1985
- Drosophila melanogaster mutations suppressible by the suppressor of Hairy-wing are insertions of a 7.3-kilobase mobile element.Proceedings of the National Academy of Sciences of the United States of America, 1983
- Patterns of pigmentation color states regulated by the y locus in Drosophila melanogasterDevelopmental Biology, 1976
- Genetic regulation and pattern formation: A study of theyellowlocus inDrosophila melanogasterGenetics Research, 1974