Sporadic paediatric and adult Burkitt lymphomas share similar phenotypic and genotypic features
- 1 March 2008
- journal article
- research article
- Published by Wiley in Histopathology
- Vol. 52 (4), 427-435
- https://doi.org/10.1111/j.1365-2559.2008.02974.x
Abstract
To characterize the clinicopathological features of sporadic Burkitt lymphoma (BL). A retrospective study of 17 paediatric and 14 adult BLs with history and histopathology review, immunohistochemistry, Epstein-Barr virus (EBV) in situ hybridization (EBER) and fluorescence in situ hybridization. There was no statistically significant difference in gender, frequency of central nervous system (CNS) involvement and leukaemic change at presentation, or frequency of CD10+/Bcl-2-/Bcl-6+ (88% versus 86%), Ki67 labelling index, EBER (24% versus 21%), or C-MYC translocation (100% versus 92%) between paediatric and adult tumours. Correct pretreatment diagnoses were made in 13/17 (76%) paediatric and in 9/14 (64%) adult tumours. Twenty-eight patients received chemotherapy including 13/16 (81%) paediatric and 3/12 (25%) adult patients with appropriate regimens; 16 (57%) received CNS prophylaxis. The 1- and 5-year overall survival (OS) rates for paediatric patients were 80% and 50%, respectively, whereas 1-year OS for adults was 15%. Sporadic paediatric and adult BLs were phenotypically and genotypically similar. The significant prognosticators were age (P = 0.001), with or without CNS prophylaxis (P = 0.004), and CNS involvement (P = 0.008) and leukaemic change (P = 0.019) in disease course. The poor outcome in adult patients might be related to incorrect diagnosis and inappropriate treatment.Keywords
This publication has 22 references indexed in Scilit:
- CNS prophylaxis in lymphoma: Who to target and what therapy to useBlood Reviews, 2006
- Diagnosis of Burkitt lymphoma in due time: a practical approachBritish Journal of Haematology, 2006
- Chemoimmunotherapy with hyper‐CVAD plus rituximab for the treatment of adult Burkitt and Burkitt‐type lymphoma or acute lymphoblastic leukemiaCancer, 2006
- The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95Blood, 2004
- Homogeneous immunophenotype and paucity of secondary genomic aberrations are distinctive features of endemic but not of sporadic Burkitt's lymphoma and diffuse large B‐cell lymphoma with MYC rearrangementThe Journal of Pathology, 2004
- Comparative Immunohistochemical Analysis of Pediatric Burkitt Lymphoma and Diffuse Large B-Cell LymphomaAmerican Journal of Clinical Pathology, 2004
- CNS Prophylaxis and Treatment in Non-Hodgkin's Lymphoma: Variation in Practice and Lessons from the LiteratureLeukemia & Lymphoma, 2003
- Multicolor-FICTIONThe American Journal of Pathology, 2002
- Expression of EBV Encoded Nuclear Small Non-Polyadenylated RNA (EBER) Molecules in 32 Cases of Childhood Burkitt's Lymphoma from IsraelLeukemia & Lymphoma, 2001
- Association of Burkitt's Lymphoma with the Epstein-Barr Virus in Two Developing CountriesLeukemia & Lymphoma, 2000