Iodinated melatonin mimics melatonin action and reveals discrete binding sites in fetal brain
- 8 February 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 228 (1), 123-127
- https://doi.org/10.1016/0014-5793(88)80599-4
Abstract
Iodinated melatonin was used to study melatonin sites of action in brain. Iodomelatonin mimicked the effects of melatonin on reproductive development in Djungarian hamster fetuses. 125I-melatonin injected into the dam was recovered from fetal brain. In vitro autoradiographic studies revealed a remarkably discrete distribution of competitive 125I-melatonin-binding sites in the fetal brain, with binding in median eminence/arcuate nucleus area > suprachiasmatic nucleus > pineal gland ⪢ anterior pituitary gland ⪢ preoptic area. 125I-melatonin promises to be a useful tool for understanding the sites and mechanism of action of melatonin.Keywords
This publication has 16 references indexed in Scilit:
- Hypothalamic melatonin receptor sites revealed by autoradiographyBrain Research, 1987
- HPLC-purified 2-[125I]iodomelatonin labels multiple binding sites in hamster brainBiochemical and Biophysical Research Communications, 1987
- Use of 2-[125I]iodomelatonin to characterize melatonin binding sites in chicken retina.Proceedings of the National Academy of Sciences, 1987
- A Brain Site for the Antigonadal Action of Melatonin in the White-Footed Mouse (Peromyscus (leucopus): Involvement of the Immunoreactive GnRH Neuronal SystemNeuroendocrinology, 1987
- Impact of circulating estradiol on melatonin binding sites in discrete areas of the female rat brainBrain Research, 1986
- Short Photoperiod-Induced Gonadal Regression: Effects on the Gonadotropin-Releasing Hormone (GnRH) Neuronal System of the White-Footed Mouse, Peromyscus LeucopusBiology of Reproduction, 1986
- Melatonin: A Coordinating Signal for Mammalian Reproduction?Science, 1985
- Iodinated melatonin: Preparation and characterization of the molecular structure by mass and 1H NMR spectroscopyAnalytical Biochemistry, 1984
- MATERNAL-FETAL TRANSFER OF MELATONIN IN THE NON-HUMAN PRIMATEPediatric Research, 1979
- Melatonin Inhibition of the Neonatal Pituitary Response to Luteinizing Hormone-Releasing FactorScience, 1976