Veins in plaques of multiple sclerosis patients – a longitudinal magnetic resonance imaging study at 7 Tesla –
- 23 April 2015
- journal article
- magnetic resonance
- Published by Springer Science and Business Media LLC in European Radiology
- Vol. 25 (10), 2913-2920
- https://doi.org/10.1007/s00330-015-3719-y
Abstract
To monitor the venous volumes in plaques of patients with multiple sclerosis (MS) compared to an age-matched control group over a period of 3.5 years. Ten MS patients underwent an annual neurological examination and MRI. Susceptibility-weighted imaging (SWI) combined with fluid-attenuated inversion recovery (FLAIR) or FLAIR-like contrast at 7 Tesla (7 T) magnetic resonance imaging (MRI) was used for manual segmentation of veins in plaques, in the normal-appearing white matter (NAWM) and in location-matched white matter of 9 age-matched controls. Venous volume to tissue volume ratio was assessed for each time point in order to describe the dynamics of venous volumes in MS plaques over time. MS plaques, which were newly detected during the study period, showed significantly higher venous volumes compared to the preplaque area 1 year before plaque detection and the corresponding NAWM regions. Venous volumes in established MS plaques, which were present already in the first scans, were significantly higher compared to the NAWM and controls. Our data underpin a relation of veins and plaque development in MS and reflect increased apparent venous calibers due to increased venous diameters or increased oxygen consumption in early MS plaques. • Longitudinal 7 T Magnetic Resonance Imaging study of intralesional veins in MS patients. • Venous volumes are significantly increased in newly detected and established MS plaques. • Venous volumes in established MS plaques show a trend to decrease with time.Keywords
This publication has 43 references indexed in Scilit:
- Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 TeslaBrain, 2011
- Decreased brain venous vasculature visibility on susceptibility-weighted imaging venography in patients with multiple sclerosis is related to chronic cerebrospinal venous insufficiencyBMC Neurology, 2011
- A Comparison of 3T and 7T in the Detection of Small Parenchymal Veins Within MS LesionsInvestigative Radiology, 2009
- White matter hemodynamic abnormalities precede sub-cortical gray matter changes in multiple sclerosisJournal of the Neurological Sciences, 2009
- Diminished visibility of cerebral venous vasculature in multiple sclerosis by susceptibility‐weighted imaging at 3.0 TeslaJournal of Magnetic Resonance Imaging, 2009
- The relation between inflammation and neurodegeneration in multiple sclerosis brainsBrain, 2009
- Mitochondrial changes within axons in multiple sclerosisBrain, 2009
- Chronic cerebrospinal venous insufficiency in patients with multiple sclerosisJournal of Neurology, Neurosurgery & Psychiatry, 2008
- Seven-Tesla Magnetic Resonance ImagingArchives of Neurology, 2008
- Pattern of hemodynamic impairment in multiple sclerosis: Dynamic susceptibility contrast perfusion MR imaging at 3.0 TNeuroImage, 2006