Diagnosis of Human Allergy Utilizing Passive Skin-Sensitization in the Monkey Macaca irus.
- 1 December 1961
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 108 (3), 623-626
- https://doi.org/10.3181/00379727-108-27015
Abstract
Summary Blood sera from patients suffering from castorbean-allergy will sensitize the skin of the Philippine crab-eating monkey, Macaca irus. The sensitized sites react to castorbean proteins, producing wheals and/or blanching characteristic of similar passive transfer tests (P.-K. tests) in nonallergic human volunteers. Skin reactions in the monkey are more easily interpreted when the colloidal dye Evans Blue is injected intravenously 5 or 10 minutes prior to challenge with the suspected allergenic material. The passive transfer of human serum antibodies into the skin of Macaca irus appears to be useful as a method which may be applied in lieu of the Prausnitz-Küstner test (on human volunteers) to avoid the grave risk of infection with serum hepatitis.Keywords
This publication has 2 references indexed in Scilit:
- Electrophoretic fractionation of soluble antigenic proteins from the seed ofRicinus communis (castor bean)Journal of Oil & Fat Industries, 1961
- Passive cutaneous anaphylaxis in the detection of seed antigens ofRicinus communis (castorbean)Journal of Oil & Fat Industries, 1961