Autocrine Induction of Collagenase by Serum Amyloid A-Like and β 2 -Microglobulin-Like Proteins
- 3 February 1989
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 243 (4891), 655-657
- https://doi.org/10.1126/science.2536953
Abstract
Two autocrine proteins of 14 and 12 kilodaltons that induce the synthesis of rabbit fibroblast collagenase were identified. The proteins were purified from serum-free culture medium taken from rabbit synovial fibroblasts stimulated with phorbol myristate acetate. The amino-terminal sequences of the 14- and 12-kilodalton species were approximately 60 to 80 percent homologous with serum amyloid A and beta 2 microglobulin, respectively. The polyacrylamide gel-eluted proteins retained the ability to induce collagenase synthesis in rabbit and human fibroblasts. These autocrine proteins may provide a means to modulate collagenase synthesis in normal remodeling as well as in inflammation and disease states.This publication has 30 references indexed in Scilit:
- Autocrine control of collagenase synthesis by synovial fibroblastsJournal of Cellular Physiology, 1988
- Growth factors and the regulation of bone remodeling.JCI Insight, 1988
- A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitorsNature, 1988
- Cloning of a complementary dna for rabbit proactivator. a metalloproteinase that activates synovial cell collagenase, shares homology with stromelysin and transin, and is coordinately regulated with collagenaseArthritis & Rheumatism, 1987
- Characterization of murine monoclonal antibodies directed against basic fibroblast growth factorJournal of Cellular Physiology, 1987
- Substance P Activation of Rheumatoid Synoviocytes: Neural Pathway in Pathogenesis of ArthritisScience, 1987
- DNA sequence evidence for polymorphic forms of human serum amyloid A (SAA)Biochemical Genetics, 1986
- Chondrocyte activation in response to factor(s) produced by a continuous line of lapine synovial fibroblastsExperimental Cell Research, 1986
- Localization of human SAA gene(s) to chromosome 11 and detection of DNA polymorphismsBiochemical and Biophysical Research Communications, 1986
- Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.The Journal of Experimental Medicine, 1985