Reduction of Glutamic Pyruvic Transaminase in Pyridoxine Deficiency in Liver Disease.

Abstract

Summary and Conclusions Hepatic glutamic pyruvic transaminase activity is decreased in diet induced B₆ deficiency and so prevents or diminishes increases in serum glutamic pyruvic transaminase following liver cell necrosis. Pyridoxine treatment restores normal tissue and serum glutamic pyruvic transaminase activity in uncomplicated vitamin B₆ deficiency; in contrast, low enzyme activity may persist in severe liver injury, despite pyridoxine administration.