Treatment with essential amino acids in patients on chronic hemodialysis: a double blind cross-over study
Open Access
- 1 October 1978
- journal article
- clinical trial
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 31 (10), 1821-1826
- https://doi.org/10.1093/ajcn/31.10.1821
Abstract
Patients on chronic hemodialysis may suffer from a latent protein deficiency, and therapy with essential amino acids has been recommended. In a double blind cross-over study, 13 hemodialysis patients received orally 15.7 g of essential amino acids daily over a 3-month period. Patients were on a liberal diet, containing 1 g of protein per kilogram of body weight per day. Hemodialysis was adequate. Therapy resulted in an increase in urea, uric acid, C3 c complement factor and a fall in C4. Lysine levels increased and phenylalanine fell. Malnutrition could not account for the observed metabolic changes, which are more likely due to uremic metabolic disturbances. A liberal diet of 1 g of protein per kilogram of body weight appears sufficient for patients on hemodialysis. Treatment with essential amino acids offers no advantage.Keywords
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