In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain
Open Access
- 22 June 2009
- journal article
- Published by Springer Science and Business Media LLC in BMC Neuroscience
- Vol. 10 (1), 63
- https://doi.org/10.1186/1471-2202-10-63
Abstract
In vivo proton magnetic resonance spectroscopy (1H-MRS) studies of HIV-infected humans have demonstrated significant metabolic abnormalities that vary by brain region, but the causes are poorly understood. Metabolic changes in the frontal cortex, basal ganglia and white matter in 18 SIV-infected macaques were investigated using MRS during the first month of infection. Changes in the N-acetylaspartate (NAA), choline (Cho), myo-inositol (MI), creatine (Cr) and glutamine/glutamate (Glx) resonances were quantified both in absolute terms and relative to the creatine resonance. Most abnormalities were observed at the time of peak viremia, 2 weeks post infection (wpi). At that time point, significant decreases in NAA and NAA/Cr, reflecting neuronal injury, were observed only in the frontal cortex. Cr was significantly elevated only in the white matter. Changes in Cho and Cho/Cr were similar across the brain regions, increasing at 2 wpi, and falling below baseline levels at 4 wpi. MI and MI/Cr levels were increased across all brain regions. These data best support the hypothesis that different brain regions have variable intrinsic vulnerabilities to neuronal injury caused by the AIDS virus.Keywords
This publication has 55 references indexed in Scilit:
- Changes in MRS neuronal markers and T cell phenotypes observed during early HIV infectionNeurology, 2009
- Factor analysis reveals differences in brain metabolism in macaques with SIV/AIDS and those with SIV‐induced encephalitisNMR in Biomedicine, 2008
- Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAIDSMagnetic Resonance in Medicine, 2008
- Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairmentAIDS, 2006
- Cortical NAA Deficits in HIV Infection without Dementia: Influence of Alcoholism ComorbidityNeuropsychopharmacology, 2005
- A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementiaJournal of Magnetic Resonance Imaging, 2005
- A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to ageNeuroImage, 2004
- Regional patterns of brain metabolites in AIDS dementia complexNeuroImage, 2004
- Metabolites in ventricular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imagingJournal of Magnetic Resonance Imaging, 2004
- Estimation of metabolite concentrations from localized in vivo proton NMR spectraMagnetic Resonance in Medicine, 1993