Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide
- 8 January 2007
- journal article
- Published by Elsevier BV in Archives of Biochemistry and Biophysics
- Vol. 458 (2), 167-174
- https://doi.org/10.1016/j.abb.2006.12.021
Abstract
No abstract availableThis publication has 32 references indexed in Scilit:
- Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxideProtein Engineering, Design and Selection, 2006
- A Rational Approach to Re-engineer Cytochrome P450 2B1 Regioselectivity Based on the Crystal Structure of Cytochrome P450 2C5Journal of Biological Chemistry, 2003
- The many roles of cytochrome b5Pharmacology & Therapeutics, 2003
- The roles of cytochrome b5 in cytochrome P450 reactionsJournal of Biochemical and Molecular Toxicology, 2002
- Substrate Routes to the Buried Active Site May Vary among Cytochromes P450: Mutagenesis of the F−G Region in P450 2B1Chemical Research in Toxicology, 2002
- Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylaseNature Biotechnology, 2002
- A Truncation of 2B Subfamily Cytochromes P450 Yields Increased Expression Levels, Increased Solubility, and Decreased Aggregation While Retaining FunctionArchives of Biochemistry and Biophysics, 2001
- Random Mutagenesis of Human Cytochrome P450 2A6 and Screening with Indole Oxidation Products1Archives of Biochemistry and Biophysics, 2001
- Analysis of Mammalian Cytochrome P450 Structure and Function by Site-Directed MutagenesisCurrent Drug Metabolism, 2001
- Formation of Indigo by Recombinant Mammalian Cytochrome P450Biochemical and Biophysical Research Communications, 1999