In vitro Efficacy of Cefquinome (INN) and other Anti‐infective Drugs against Bovine Bacterial Isolates from Belgium, France, Germany, The Netherlands, and the United Kingdom
- 12 January 1995
- journal article
- research article
- Published by Wiley in Journal of Veterinary Medicine, Series B
- Vol. 42 (1-10), 377-383
- https://doi.org/10.1111/j.1439-0450.1995.tb00724.x
Abstract
The in vitro antibacterial activity of cefquinome (INN), an aminothiazolyl-cephalosporin of the fourth generation of cephalosporins, was investigated by determining the minimal inhibitory concentration (MIC, microgram/ml) for 714 bacterial isolates of bovine origin and comparing it with those of amoxicillin, amoxicillin and clavulanic acid, ceftiofur, cephapirin, enrofloxacin, gentamicin, kanamycin and oxytetracycline. Drug resistance was determined by using break-points, which consider the dosage regimen and pharmacokinetics of the veterinary antimicrobials investigated. Cefquinome demonstrated a very high in vitro activity against bacterial isolates of Pasteurella spp., Escherichia coli and Salmonella spp. Overall, the level of resistance against the different anti-infectives tested was lowest for cefquinome. For the remaining substances examined, in vitro activity and the level of resistance showed considerable differences. The chemical and pharmaceutical features of cefquinome are discussed.Keywords
This publication has 8 references indexed in Scilit:
- Comparative Antibacterial Activity of the Aminothiazolyl Cephalosporin RU 29 246Chemotherapy, 1993
- Overview of the development of a new class of β-lactam antibiotics: The carbacephemsAntimicrobic Newsletter, 1992
- Factors involved in the enhanced efficacy against Gram-negative bacteria of fourth generation cephalosporinsJournal of Antimicrobial Chemotherapy, 1992
- Antibacterial activities in vitro and in vivo and pharmacokinetics of cefquinome (HR 111V), a new broad-spectrum cephalosporinAntimicrobial Agents and Chemotherapy, 1991
- Recent Developments in the Field of Cephem AntibioticsPublished by Elsevier BV ,1988
- Antibiotic susceptibility testing: caeci caecos ducentes?Veterinary Record, 1983
- Structure-Activity Relations of New β-Lactam Compounds and in Vitro Activity Against Common BacteriaClinical Infectious Diseases, 1983
- In Vitro Veritas? Antimicrobial Susceptibility Tests and Their Clinical RelevanceThe Journal of Infectious Diseases, 1981