Erionite exposure in North Dakota and Turkish villages with mesothelioma
Open Access
- 25 July 2011
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 108 (33), 13618-13623
- https://doi.org/10.1073/pnas.1105887108
Abstract
Exposure to erionite, an asbestos-like mineral, causes unprecedented rates of malignant mesothelioma (MM) mortality in some Turkish villages. Erionite deposits are present in at least 12 US states. We investigated whether increased urban development has led to erionite exposure in the United States and after preliminary exploration, focused our studies on Dunn County, North Dakota (ND). In Dunn County, ND, we discovered that over the past three decades, more than 300 miles of roads were surfaced with erionite-containing gravel. To determine potential health implications, we compared erionite from the Turkish villages to that from ND. Our study evaluated airborne point exposure concentrations, examined the physical and chemical properties of erionite, and examined the hallmarks of mesothelial cell transformation in vitro and in vivo. Airborne erionite concentrations measured in ND along roadsides, indoors, and inside vehicles, including school buses, equaled or exceeded concentrations in Boyali, where 6.25% of all deaths are caused by MM. With the exception of outdoor samples along roadsides, ND concentrations were lower than those measured in Turkish villages with MM mortality ranging from 20 to 50%. The physical and chemical properties of erionite from Turkey and ND are very similar and they showed identical biological activities. Considering the known 30- to 60-y latency for MM development, there is reason for concern for increased risk in ND in the future. Our findings indicate that implementation of novel preventive and early detection programs in ND and other erionite-rich areas of the United States, similar to efforts currently being undertaken in Turkey, is warranted.Keywords
This publication has 33 references indexed in Scilit:
- Malignant mesothelioma: Facts, Myths, and HypothesesJournal of Cellular Physiology, 2011
- Morphological and Chemical Mechanisms of Elongated Mineral Particle ToxicitiesJournal of Toxicology and Environmental Health, Part B, 2011
- Pleural Mesothelioma in New Caledonia: Associations with Environmental Risk FactorsEnvironmental Health Perspectives, 2011
- Exposure to Asbestos-Containing Vermiculite Ore and Respiratory Symptoms among Individuals Who Were Children While the Mine Was Active in Libby, MontanaEnvironmental Health Perspectives, 2010
- Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammationProceedings of the National Academy of Sciences, 2010
- Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: Results in 663 patientsThe Journal of Thoracic and Cardiovascular Surgery, 2008
- TNF-α inhibits asbestos-induced cytotoxicity via a NF-κB-dependent pathway, a possible mechanism for asbestos-induced oncogenesisProceedings of the National Academy of Sciences, 2006
- Modern Criteria to Establish Human Cancer EtiologyCancer Research, 2004
- Malignant pleural mesothelioma caused by environmental exposure to asbestos or erionite in rural Turkey: CT findings in 84 patients.American Journal of Roentgenology, 1993
- Zeolites in Sedimentary Deposits of the United States—A ReviewPublished by American Chemical Society (ACS) ,1974