Progressive Glomerulonephritis and Histiocytic Sarcoma Associated with Macrophage Functional Defects in CYP1B1-Deficient Mice
Open Access
- 1 October 2004
- journal article
- research article
- Published by SAGE Publications in Toxicologic Pathology
- Vol. 32 (6), 710-718
- https://doi.org/10.1080/01926230490885706
Abstract
The cytochrome P450 CYP1B1 enzyme metabolically activates polycyclic aromatic hydrocarbons and is a major P450 isoenzyme in human monocytes and macrophages. We have shown previously that mice defic...Keywords
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