Successful Treatment of Juvenile Chronic Granulocytic Leukemia With Marrow Transplantation

Abstract

A 46 mo. old boy with juvenile chronic granulocytic leukemia was treated intensively with hydroxyurea, dimethyl myleran, cyclophosphamide and total body irradiation. He then received a marrow transplant from an HLA matched brother. Thirty-two mo. after the transplantation, he is hematologically normal and remains disease free on no-maintenance therapy. The successful outcome of this case suggests that a bone marrow transplant for any patient with a suitable histocompatible donor should be considered in the treatment of this disease.