L-Dopa: Disaggregation of Brain Polysomes and Elevation of Brain Tryptophan
- 27 August 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 173 (3999), 833-835
- https://doi.org/10.1126/science.173.3999.833
Abstract
One hour after administration of L-dopa (50 to 300 milligrams per kilogram), there is a marked disaggregation of brain polysomes in immature rats. Adult animals show a similar response, but require larger doses of the amino acid (500 milligrams per kilogram). Single doses of L-dopa significantly elevate amounts of tryptophan in the brain; hence their effect on polysomes does not result from the unavailability of this amino acid.Keywords
This publication has 16 references indexed in Scilit:
- L-Dopa-Induced Release of Cerebral MonoaminesScience, 1970
- L-Dihydroxyphenylalanine: Effect on S -Adenosylmethionine in BrainScience, 1970
- L-Dopa: Effect on Concentrations of Dopamine, Norepinephrine, and Serotonin in Brains of MiceScience, 1970
- Hyperphenylalaninemia: Disaggregation of Brain Polyribosomes in Young RatsScience, 1970
- Treatment of Parkinsonism With LevodopaArchives of Neurology, 1969
- Regulation of polysome aggregation in a cell-free system through ammo acid supplyJournal of Molecular Biology, 1968
- Comparison of the effect of amino acid supply on hepatic polysome profiles in vivo and in vitroBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1968
- Specificity of Cerebral Amino Acid Transport: A Kinetic AnalysisProgress in brain research, 1968
- Circadian Rhythm for Tryptophan Pyrrolase Activity and Its Circulating SubstrateScience, 1966
- The action of antidecarboxylases on the conversion of 3,4-dihydroxyphenylalanine to dopamine in vivoArchives of Biochemistry and Biophysics, 1961