Mechanisms of transactivation by retinoic acid receptors
- 1 May 1993
- Vol. 15 (5), 309-315
- https://doi.org/10.1002/bies.950150504
Abstract
Retinoids play an important role in development and differentiation(1,2). Their effect is mediated through nuclear receptors, RAR (α, β and γ) and RXR (α, β and γ),† which are members of a distinct subclass (hereafter referred to as type II) of the nuclear receptor superfamily that includes the thyroid hormone receptor (T3R), the vitamin D3 receptor (VD3R) and the peroxisome proliferator activated receptor (PPAR). Type II receptors transactivate through binding sites composed of closely related half‐sites (consensus sequence AGG/T TCA) arranged as direct repeats and, with the possible exception of RXR, do not bind to their cognate binding sites as homodimers but require RXR for high affinity binding. RXR thus provides a link between biologically distinct ligand induced pathways and is a potential target for cross‐regulation. In addition, RAR can utilize alternative routes to enhance transcription initiation mediated through transcriptional co‐activators which are expressed in a cell‐type specific manner.Keywords
This publication has 57 references indexed in Scilit:
- Homodimer formation of retinoid X receptor induced by 9-cis retinoic acidNature, 1992
- Homo- and heteronuclear NMR studies of the human retinoic acid receptor .beta. DNA-binding domain: sequential assignments and identification of secondary structure elementsBiochemistry, 1992
- Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signallingNature, 1992
- Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptorsNature, 1992
- 9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRαNature, 1992
- Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptorsCell, 1991
- Mechanism of action of an acidic transcriptional activator in vitroCell, 1991
- Steroid hormone receptors and In vitro transcriptionBioEssays, 1991
- Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene productNature, 1989
- An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cellsCell, 1987