Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones.
- 1 May 1986
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 83 (10), 3537-3541
- https://doi.org/10.1073/pnas.83.10.3537
Abstract
Growth-associated protein, GAP-43, is a polypeptide that is induced in neurons when they grow axons. We show by means of subcellular fractionation and immunohistochemical localization that GAP-43 is a component of neuronal growth cones as well as growing neurites; it is similar to a major phosphoprotein, pp46, of a growth cone-enriched subcellular fraction. These conclusions are consistent with the possibility that the induction of GAP-43/pp46 is an important event in the establishment of a productive growth state in which a neuron is competent to extend an axon.This publication has 19 references indexed in Scilit:
- Characteristics of growth-associated polypeptides in regenerating toad retinal ganglion cell axonsJournal of Neuroscience, 1981
- Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systemsThe Journal of cell biology, 1981
- Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells.The Journal of cell biology, 1981
- Specific changes in rapidly transported proteins during regeneration of the goldfish optic nerveJournal of Neuroscience, 1981
- A simplified ultrasensitive silver stain for detecting proteins in polyacrylamide gelsAnalytical Biochemistry, 1980
- Purification and Some Characteristics of an ACTH‐Sensitive Protein Kinase and Its Substrate Protein in Rat Brain MembranesJournal of Neurochemistry, 1980
- A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry, 1976
- Endogenous phosphorylation of four cerebral cortical membrane proteins: Role of cyclic nucleotides, ATP and divalent cationsBrain Research, 1975
- Studies on the transplantation of spinal cord tissue in the rat. I. The development of a culture system for hemisections of embryonic spinal cordBrain Research, 1973
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970