Brain Natriuretic Peptide Is a Prognostic Parameter in Chronic Lung Disease
- 1 April 2006
- journal article
- research article
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 173 (7), 744-750
- https://doi.org/10.1164/rccm.200510-1545oc
Abstract
The detection of pulmonary hypertension in patients with chronic lung disease has prognostic implications. The brain natriuretic peptide (BNP) has been suggested as a noninvasive marker for the presence and severity of pulmonary hypertension. We evaluated circulating BNP levels as a parameter for the presence and severity of pulmonary hypertension in patients with chronic lung disease. BNP levels were measured in 176 consecutive patients with various pulmonary diseases. Right heart catheterization, lung functional testing, and a 6-min walk test were performed. The mean follow-up time was nearly 1 yr. Significant pulmonary hypertension (mean pulmonary artery pressure > 35 mm Hg) was diagnosed in more than one-fourth of patients and led to decreased exercise tolerance and life expectancy. Elevated BNP concentrations identified significant pulmonary hypertension with a sensitivity of 0.85 and specificity of 0.88 and predicted mortality. Moreover, BNP served as a risk factor of death independent of lung functional impairment or hypoxemia in uni- and multivariate analysis. We suggest BNP as a prognostic marker and as screening parameter for significant pulmonary hypertension in chronic lung disease.Keywords
This publication has 32 references indexed in Scilit:
- Long-Term Response to Calcium Channel Blockers in Idiopathic Pulmonary Arterial HypertensionCell Metabolism, 2005
- Clinical classification of pulmonary hypertensionJournal of the American College of Cardiology, 2004
- Clinical significance of brain natriuretic peptide in primary pulmonary hypertensionJournal of the American College of Cardiology, 2004
- Plasma Natriuretic Peptide Levels and the Risk of Cardiovascular Events and DeathNew England Journal of Medicine, 2004
- B-Type Natriuretic Peptides and Ejection Fraction for Prognosis After Myocardial InfarctionCell Metabolism, 2003
- CHRONIC COR PULMONALEHeart, 2003
- Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: Relation to hemodynamic variables and endothelin levelsJournal of the American College of Cardiology, 1995
- Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.JCI Insight, 1991
- Prognostic value of pulmonary artery pressure in chronic obstructive pulmonary disease.Thorax, 1981
- Arterialized capillary blood gases in exercise studiesMedicine & Science in Sports & Exercise, 1975