Excitotoxins in Neuronal Apoptosis and Necrosis
Open Access
- 1 June 1999
- journal article
- review article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 19 (6), 583-591
- https://doi.org/10.1097/00004647-199906000-00001
Abstract
Neuronal loss is common to many neurodegenerative diseases. Although necrosis is a common histopathologic feature observed in neuropathologic conditions, evidence is increasing that apoptosis can significantly contribute to neuronal demise. The prevalence of either type of cell death, apoptosis or necrosis, and the relevance for the progression of disease is still unclear. The debate on the occurrence and prevalence of one or the other type of death in pathologic conditions such as stroke or neurotoxic injury may in part be resolved by the proposal that different types of cell death within a tissue reflect either partial or complete execution of a common death program. Apoptosis is an active process of cell destruction, characterized morphologically by cell shrinkage, chromatin aggregation with extensive genomic fragmentation, and nuclear pyknosis. In contrast, necrosis is characterized by cell swelling, linked to rapid energy loss, and generalized disruption of ionic and internal homeostasis. This swiftly leads to membrane lysis, release of intracellular constituents that evoke a local inflammatory reaction, edema, and injury to the surrounding tissue. During the past few years, our laboratories have studied the signals and mechanisms responsible for induction or prevention of apoptosis/necrosis in neuronal injury and this is the subject of this review.Keywords
This publication has 71 references indexed in Scilit:
- Techniques for Distinguishing Apoptosis from Necrosis in Cerebrocortical and Cerebellar NeuronsPublished by Springer Science and Business Media LLC ,2003
- Mechanisms of Reduced Striatal NMDA Excitotoxicity in Type I Nitric Oxide Synthase Knock-Out MiceJournal of Neuroscience, 1997
- Programmed cell death in brains of HIV-1-positive AIDS and pre-AIDS patientsActa Neuropathologica, 1996
- Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial functionNeuron, 1995
- Programmed cell death in brains of HIV-1-positive pre-AIDS patientsThe Lancet, 1995
- Neuronal apoptosis in HIV infection in adultsNeuropathology and Applied Neurobiology, 1995
- Hydrogen peroxide mediates amyloid β protein toxicityCell, 1994
- Role of excitotoxicity in human neurological diseaseCurrent Opinion in Neurobiology, 1992
- Redox Regulation of Fos and Jun DNA-Binding Activity in VitroScience, 1990
- Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.Proceedings of the National Academy of Sciences, 1990