In vivo31P spectroscopy by fully adiabatic extended image selected in vivo spectroscopy: A comparison between 3 T and 7 T
Open Access
- 28 March 2011
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 66 (4), 923-930
- https://doi.org/10.1002/mrm.22897
Abstract
An improved image selected in vivo spectroscopy (ISIS) sequence for localized 31P magnetic resonance spectroscopy at 7 T was developed. To reduce errors in localization accuracy, adiabatic excitation, gradient offset independent adiabatic inversion pulses, and a special extended ISIS ordering scheme were used. The localization accuracy of extended ISIS was investigated in phantoms. The possible spectral quality and reproducibility in vivo was explored in a volunteer (brain, muscle, and liver). A comparison between 3 T and 7 T was performed in five volunteers. Adiabatic extended ISIS provided high spectral quality and accurate localization. The contamination in phantom experiments was only ∼5%, even if a pulse repetition time ∼ 1.2·T1 was chosen to maximize the signal‐to‐noise ratio per unit time. High reproducibility was found in the calf muscle for 2.5 cm isotropic voxels at 7 T. When compared with 3 T, localized 31P magnetic resonance spectroscopy in the human calf muscle at 7 T provided ∼3.2 times higher signal‐to‐noise ratio (as judged from phosphocreatine peak amplitude in frequency domain after matched filtering). At 7 T, extended ISIS allowed the performance of high‐quality localized 31P magnetic resonance spectroscopy in a short measurement time (∼3 to 4 min) and isotropic voxel sizes of ∼2.5 to 3 cm. With such short measurement times, localized 31P magnetic resonance spectroscopy has the potential to be applied not only for clinical research but also for routine clinical practice. Magn Reson Med, 2011.Keywords
Funding Information
- OeNB Jubilaeumsfond (13629, 13834)
- Vienna Spots of Excellence des Wiener Wissenschafts-und Technologie-Fonds (WWTF)-Vienna Advanced Imaging Center (VIACLIC)
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