MicroRNAs in cell proliferation, cell death, and tumorigenesis
Open Access
- 21 February 2006
- journal article
- review article
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 94 (6), 776-780
- https://doi.org/10.1038/sj.bjc.6603023
Abstract
MicroRNAs (miRNAs) are a recently discovered class of ∼18–24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.Keywords
This publication has 38 references indexed in Scilit:
- miR-15 and miR-16 induce apoptosis by targeting BCL2Proceedings of the National Academy of Sciences, 2005
- High expression of precursor microRNA‐155/BIC RNA in children with Burkitt lymphomaGenes, Chromosomes and Cancer, 2003
- Reduced accumulation of specific microRNAs in colorectal neoplasia.2003
- Genomic targets of the human c-Myc proteinGenes & Development, 2003
- The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat MetabolismCurrent Biology, 2003
- bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in DrosophilaCell, 2003
- Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsGenes & Development, 2003
- Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemiaProceedings of the National Academy of Sciences, 2002
- Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNANature, 2000
- Loss of heterozygosity at chromosome 13q in hepatocellular carcinoma: identification of three independent regionsEuropean Journal Of Cancer, 1999