Improved bio‐implant using ultrafast laser induced self‐assembled nanotexture in titanium
- 10 March 2011
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Vol. 97B (2), 299-305
- https://doi.org/10.1002/jbm.b.31815
Abstract
The most successful metal implant materials currently have relatively smooth surfaces on the micron size scale, with most failures occurring after only 10 years. To move beyond this limiting time scale, texturing methods have been developed to modify the metal surface to enhance integration of the implant directly with surrounding bone. A flexible single‐step ultrafast‐laser texturing process has been developed that results in a surface texture that exhibits micron scale peaks and troughs with superimposed submicron and nano‐scale features. The textured titanium samples remain completely hydrophilic with no measurable contact angle even after several weeks in normal atmosphere. An increase in mesenchymal stem cell number is observed over that on an untreated control titanium surface. Extensive formation of cellular bridges by stromal cells between pillars shows the favorable response of differentiated cells to the surface and the promotion of their attachment. Expression of the alkaline phosphatase and osteocalcin genes in human bone marrow cells were seen to increase on the textured surface. The development of this single‐step method for creating micron, submicron, and nano‐scale surface texture directly on metals makes a significant contribution to the goal of improving the integration and life span of joint replacement implants. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.Keywords
This publication has 33 references indexed in Scilit:
- Physicochemical Investigation of Pulsed Laser Deposited Carbonated Hydroxyapatite Films on TitaniumACS Applied Materials & Interfaces, 2009
- Evaluation of CO2‐based cold sterilization of a model hydrogelBiotechnology & Bioengineering, 2008
- Adenovirus-mediated expression of growth and differentiation factor-5 promotes chondrogenesis of adipose stem cellsGrowth Factors, 2008
- The New Demands by Patients in the Modern Era of Total Joint ArthroplastyClinical Orthopaedics & Related Research, 2008
- Knee Arthroplasty in the Young PatientClinical Orthopaedics & Related Research, 2007
- Spontaneous formation of nanospiked microstructures in germanium by femtosecond laser irradiationNanotechnology, 2007
- Requirement for both micron- and submicron scale structure for synergistic responses of osteoblasts to substrate surface energy and topographyBiomaterials, 2007
- Demineralized bone matrix gelatin as scaffold for osteochondral tissue engineeringBiomaterials, 2005
- Human osteoblast cells: Isolation, characterization, and growth on polymers for musculoskeletal tissue engineeringJournal of Biomedical Materials Research Part A, 2005
- Macro-structural effect of metal surfaces treated using computer-assisted yttrium-aluminum-garnet laser scanning on bone-implant fixationJournal of Biomedical Materials Research Part A, 2005