The location of the polio genome protein in viral RNAs and its implication for RNA synthesis
- 1 July 1977
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 268 (5617), 208-213
- https://doi.org/10.1038/268208a0
Abstract
Evidence is presented that a small protein (VPg) is covalently attached to the 5''-terminal oligonucleotide VPg-pU-U-A-A-A-A-C-A-Gp of the polio genome, to nascent strands of the polio replicative intermediate and to poly(U) of minus strands. A model of polio RNA replication is proposed implicating VPg in initiation of RNA synthesis, possibly as primer.This publication has 22 references indexed in Scilit:
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