Use of Polymyxin in Gram Negative Urinary Tract Infections

Abstract

- -The in vitro and in vivo effectiveness of poly-myxin against Gram-negative bacilli responsible for infection of the urinary tract was studied. In vitro, polymyxin is markedly inhibitory for Salmonella, Shigella. Klebsiella. the coli-aerogenes spp. and Pseudomonas. Brucella and selected strains of staphylococci are moderately sensitive while Proteus and hemolytic streptococci are refractory. Proteus requires 100 to more than 100 ug./ml. of polymyxin. With a daily dose of 3 mg./kg. of body wt. the concn. of the drug in the urine ranges between 40 and 400 ug./ml. after 24 hrs. Of 31 cases, 17 benefited from polymyxin therapy.