MECHANISM OF PROTEINURIA

Abstract

Intraperitoneal administration of bovine albumin sharply increases glomerular permeability to hemoglobin in the rat kidney. In addition, bovine albumin "saturates" the tubular absorption mechanism and inhibits the tubular absorption of subsequently administered hemoglobin. Egg white, ovalbumin, and ovomucoid, in contrast, do not produce significant changes in glomerular permeability to hemoglobin or in the tubular absorption of hemoglobin. These effects have been demonstrated both by physiologic measurements and by the morphologic demonstration of the absorbed proteins.