Boronate-Mediated Biologic Delivery
Open Access
- 3 February 2012
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 134 (8), 3631-3634
- https://doi.org/10.1021/ja210719s
Abstract
Inefficient cellular delivery limits the landscape of macromolecular drugs. Boronic acids readily form boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells. Here pendant boronic acids are shown to enhance the cytosolic delivery of a protein toxin. Thus, boronates are a noncationic carrier that can deliver a polar macromolecule into mammalian cells.Keywords
This publication has 51 references indexed in Scilit:
- Bovine Pancreatic Ribonuclease: Fifty Years of the First Enzymatic Reaction MechanismBiochemistry, 2011
- Design, Synthesis, and Screening of a Library of Peptidyl Bis(Boroxoles) as Oligosaccharide Receptors in Water: Identification of a Receptor for the Tumor Marker TF‐Antigen DisaccharideAngewandte Chemie-International Edition, 2010
- Multistep Phase-Switch Synthesis by Using Liquid-Liquid Partitioning of Boronic Acids: Productive Tags with an Expanded Repertoire of Compatible ReactionsAngewandte Chemie-International Edition, 2009
- Multivalent Benzoboroxole Functionalized Polymers as gp120 Glycan Targeted Microbicide Entry InhibitorsMolecular Pharmaceutics, 2009
- Arginine‐rich cell‐penetrating peptidesFEBS Letters, 2009
- An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cellsProceedings of the National Academy of Sciences of the United States of America, 2009
- Disruption of Shape-Complementarity Markers to Create Cytotoxic Variants of Ribonuclease AJournal of Molecular Biology, 2005
- Ficoll and dextran vs. globular proteins as probes for testing glomerular permselectivity: effects of molecular size, shape, charge, and deformabilityAmerican Journal of Physiology-Renal Physiology, 2005
- Intracellular delivery of proteins into mammalian living cells by polyethylenimine-cationizationJournal of Bioscience and Bioengineering, 2005
- Synthesis of Aromatic Boronic Acids. Aldehydo Boronic Acids and a Boronic Acid Analog of Tyrosine1Journal of the American Chemical Society, 1958