Mediators of Inflammation in Polycystic Ovary Syndrome in Relation to Adiposity
Open Access
- 8 April 2010
- journal article
- review article
- Published by Hindawi Limited in Mediators of Inflammation
- Vol. 2010, 1-5
- https://doi.org/10.1155/2010/758656
Abstract
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age group and is associated with a higher cardiovascular risk. Obesity, mainly visceral adiposity, is prevalent in patients with PCOS. Obesity is associated with low-grade inflammation and raised inflammatory cytokines, both of which are also described in patients with PCOS. In this paper, the potential relationships between fat distribution, adipocyte dysfunction and, altered inflammatory markers in patients with PCOS have been discussed.Keywords
This publication has 79 references indexed in Scilit:
- Fatty acid‐induced induction of Toll‐like receptor‐4/nuclear factor‐κB pathway in adipocytes links nutritional signalling with innate immunityImmunology, 2009
- Alterations in peripheral blood lymphocyte cytokine expression in obesityClinical and Experimental Immunology, 2006
- Obesity and polycystic ovary syndromeClinical Endocrinology, 2006
- Android subcutaneous adipose tissue topography in lean and obese women suffering from PCOS: Comparison with type 2 diabetic womenAmerican Journal of Physical Anthropology, 2003
- Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cyclesObstetrics & Gynecology, 2003
- Absence of profound hyperinsulinism in polycystic ovary syndrome is associated with subtle elevations in the plasminogen activator inhibitor systemGynecological Endocrinology, 2003
- A Specific Elevation in Tissue Plasminogen Activator Antigen in Women with Polycystic Ovarian SyndromeJournal of Clinical Endocrinology & Metabolism, 2002
- CD40 Ligation Induces Tissue Factor Expression in Human Vascular Smooth Muscle CellsThe American Journal of Pathology, 2000
- Ambulatory blood pressure profiles and plasminogen activator inhibitor (PAI‐1) activity in lean women with and without the polycystic ovary syndromeClinical Endocrinology, 1996
- Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin ResistanceScience, 1993