To identify psychological correlates of adolescent depression. The subjects (N = 156) represented a convenience sample of adolescents who were attending public high schools in four Midwestern rural communities. Instruments used were: The Center for Epidemiologic Studies Depression Scale of Children, Loneliness Inventory-Short Form, Rosenberg Self-Esteem Scale, Family Strengths Inventory, and Parent-Adolescent Communication Inventory. Higher levels of depression were associated with loneliness (r = .646, p < or = .001) and low self-esteem (r = .596, p < or = .001). Depression was negatively related to family strengths (r = -.293, p < or = .001). Older adolescents were more depressed than younger adolescents (r = .332, p < or = .001). A stepwise regression identified three pertinent factors associated with depression: loneliness, self-esteems, and age. Implications for nursing practice include interventions that minimize the exacerbating factors associated with depression in the adolescent population.