NPMMutations in Acute Myelogenous Leukemia

Abstract

Nucleophosmin (NPM) is a multifunctional phosphoprotein to which both tumor-suppressor and oncogenic functions have been attributed. Chromosomal translocations involving the NPM1 gene occur not infrequently in myeloid and lymphoid cancers. The NPM1 gene rearranges with the retinoic acid receptor α (RARα) gene in acute promyelocytic leukemia and with the anaplastic lymphoma kinase (ALK) gene in a high percentage of anaplastic large-cell lymphomas. Rearrangements with the myeloid leukemia factor 1 (MLF1) gene occur in acute myelogenous leukemia (AML), chronic myelogenous leukemia, and myelodysplasia.¹³ As a consequence of these translocations, the rearranged NPM1 allele encodes . . .