Gastric mucosal blood flow during pentagastrin‐ and histamine‐stimulated acid secretion in the rat

Abstract

1 Gastric mucosal blood flow was studied in the rat by means of a [¹⁴C]-aniline clearance technique. 2 There was a significant correlation between clearance and stimulated acid secretion. 3 No significant difference was found in the relationship between clearance and acid secretion during submaximal stimulation with either pentagastrin or histamine. 4 Estimates of mucosal blood flow per unit acid secretion by [¹⁴C]-aniline clearance in the rat were similar to those reported with aminopyrine clearance in the dog and cat.