Circumdatin H, a New Inhibitor of Mitochondrial NADH Oxidase, from Aspergillus ochraceus
- 1 June 2005
- journal article
- Published by Springer Science and Business Media LLC in The Journal of Antibiotics
- Vol. 58 (6), 416-419
- https://doi.org/10.1038/ja.2005.54
Abstract
Circumdatin H (1), a new alkaloid from the culture broth of Aspergillus ochraceus, has been isolated, together with a known circumdatin, circumdatin E (2) and other known compounds: flavacol (3) and stephacidin A (4). The structure of 1 was established on the basis of chemical and spectral evidence. All of these alkaloids showed biological activity as inhibitors of the mammalian mitochondrial respiratory chain.Keywords
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