Proposed Supplemental Dosages of Selenium for a Phase I Trial Based on Dietary and Supplemental Selenium Intakes and Episodes of Chronic Selenosis
- 1 January 1986
- journal article
- research article
- Published by SAGE Publications in Journal of the American College of Toxicology
- Vol. 5 (1), 71-78
- https://doi.org/10.3109/10915818609140737
Abstract
Phase I trials are needed to identify the maximum safe dose of both inorganic and organic selenium (Se) compounds that could be used under medical supervision for patients at extremely high risk of cancer. Based on naturally occurring episodes of chronic selenosis and experience with Se supplementation trials, we recommend a range of doses for inorganic and organic Se compounds that should be investigated in a Phase I trial in order to identify the maximum tolerated dose for these compounds.Keywords
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