Association of high plasma antioxidant capacity with new lesion formation in carotid atherosclerosis: a prospective study
- 1 October 1998
- journal article
- research article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 28 (10), 787-792
- https://doi.org/10.1046/j.1365-2362.1998.00357.x
Abstract
In atherosclerosis, both reductions and elevations in plasma levels of antioxidants have been reported. This study investigated total antioxidant capacity of plasma from subjects with atherosclerotic disease. The study population consisted of 48 men with or without carotid atherosclerosis. At baseline (1990) carotid arteries were evaluated by duplex sonography and plasma samples were obtained for testing antioxidant capacity by two different test systems. One assay system used neutrophils from healthy volunteers as a source of oxygen free radicals activating the non-fluorescent dichlorofluorescin diacetate in the presence of antioxidant containing plasma from study subjects. In the other test system, total plasma antioxidants were detected colorimetrically by using 2,2′-azino-di-(3-ethylbenzthiazoline sulphonate), metmyoglobin and superoxide in the presence of plasma. Carotid arteries were re-evaluated for the development of new plaques 5 years later (1995). Increased baseline total antioxidant capacity of plasma was significantly associated with the development of new atherosclerotic lesions during a period of 5 years. Endogenous antioxidant capacity of plasma is increased in patients with active atherosclerotic disease. As scavenging of oxygen free radicals is thought to protect from atherogenesis, elevated antioxidative capacity may represent an adaptive mechanism.Keywords
This publication has 26 references indexed in Scilit:
- Endothelial vasodilator dysfunction: Pathogenetic link to myocardial ischaemia or epiphenomenon?The Lancet, 1996
- Human suction blister interstitial fluid prevents metal ion-dependent oxidation of low density lipoprotein by macrophages and in cell-free systems.JCI Insight, 1995
- Alcohol consumption and carotid atherosclerosis: evidence of dose-dependent atherogenic and antiatherogenic effects. Results from the Bruneck Study.Stroke, 1994
- Oxygen free radicals and hypercholesterolemic atherosclerosis: Effect of vitamin EAmerican Heart Journal, 1993
- Effect of polymorphonuclear leukocyte-derived oxygen free radicals and hypochlorous acid on cardiac function and some biochemical parametersAmerican Heart Journal, 1990
- Effect of oxygen free radicals on cardiovascular function at organ and cellular levelsAmerican Heart Journal, 1989
- The Pathogenesis of Atherosclerosis — An UpdateNew England Journal of Medicine, 1986
- Oxygen-Derived Free Radicals in Postischemic Tissue InjuryNew England Journal of Medicine, 1985
- International diagnostic criteria for acute myocardial infarction and acute strokeAmerican Heart Journal, 1984
- The Electrocardiogram in Population StudiesCell Metabolism, 1960