Amitriptyline Treatment Under Chronic Stress Conditions: Effect on Circulating Catecholamines and Anxiety in Early Maternally Separated Rats
- 1 January 2009
- journal article
- research article
- Published by Informa UK Limited in International Journal of Neuroscience
- Vol. 119 (5), 664-680
- https://doi.org/10.1080/00207450802330611
Abstract
The aim of this work was to determine the effect of amitriptyline (AMI) on peripheral outcomes such as plasma epinephrine (E) and norepinephrine (NE) concentration and anxiety-like behavior displayed in the plus maze test in adult male Wistar rats under variable chronic stress and daily oral administration of AMI (5 mg/kg). Animals were previously isolated from the mother for 4.5 hr every day for the first 3 weeks of life. Administration of the antidepressant AMI reduced anxiety-like behavior in animals submitted only to chronic stress but not in early maternally separated (MS) subjects or in animals subjected to the two types of stresses.Keywords
This publication has 42 references indexed in Scilit:
- Differential neuroendocrine responses to chronic variable stress in adult Long Evans rats exposed to handling-maternal separation as neonatesPsychoneuroendocrinology, 2005
- Sex differences in rats: Effects of chronic stress on sympathetic system and anxietyPhysiology & Behavior, 2005
- The Role of the Anterodorsal Thalami Nuclei in the Regulation of Adrenal Medullary Function, Beta-adrenergic Cardiac Receptors and Anxiety Responses in Maternally Deprived Rats under Stressful ConditionsStress, 2004
- Neurobiology of DepressionNeuron, 2002
- Major Depressive DisorderNeuron, 2000
- Influence of Neonatal Rearing Conditions on Stress‐Induced Adrenocorticotropin Responses and Norepinepherine Release in the Hypothalamic Paraventricular NucleusJournal of Neuroendocrinology, 2000
- Adrenal function response to chronic stress in rats with anterodorsal thalami nuclei lesionsLife Sciences, 1995
- New animal models of anxietyEuropean Neuropsychopharmacology, 1994
- AMITRIPTYLINE ACTION ON SYMPATHETIC NEURONAL FUNCTION IN DEPRESSED WOMENClinical and Experimental Pharmacology and Physiology, 1987
- Acute and chronic stress effects on open field activity in the rat: Implications for a model of depressionNeuroscience & Biobehavioral Reviews, 1981