Copper‐Catalyzed Direct C Arylation of Heterocycles with Aryl Bromides: Discovery of Fluorescent Core Frameworks
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- 15 April 2009
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 48 (18), 3296-3300
- https://doi.org/10.1002/anie.200900413
Abstract
A window of opportunity: A general copper‐catalyzed CH bond‐activation path allows arylation of heterocycles with a wide range of aryl bromides (see scheme). The reaction shows excellent regioselectivity and exhibits good functional group tolerance. The 8‐aryl xanthines exhibit fluorescence in a variety of solvents and show promise as reagents for biological imaging.Keywords
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