Regional angiotensin II production in essential hypertension and renal artery stenosis.
- 1 February 1993
- journal article
- abstracts
- Published by Ovid Technologies (Wolters Kluwer Health) in Hypertension
- Vol. 21 (2), 173-184
- https://doi.org/10.1161/01.hyp.21.2.173
Abstract
To study regional metabolism and production of angiotensin II, we measured steady-state plasma levels of 125I-angiotensin I and II and endogenous angiotensin I and II in the aorta and the antecubital, femoral, renal, and hepatic veins during systemic infusion of 125I-angiotensin I or II. Extraction of arterially delivered angiotensin II ranged from 30-50% in the limbs to 80-100% in the renal and hepatomesenteric vascular beds both in essential hypertension (n = 13) and in unilateral renal artery stenosis (n = 7). Across the limbs, 20-30% of arterially delivered angiotensin I was converted to angiotensin II in both groups, and there was no arteriovenous gradient in endogenous angiotensin II. No conversion of arterially delivered angiotensin I was detected across the renal and hepatomesenteric beds, and there was net extraction of angiotensin II from the systemic circulation by these beds. Although regional production of angiotensin I at tissue sites made a significant contribution to its level in the veins, little of this locally produced angiotensin I reached the regional veins in the form of angiotensin II, even in the kidney with artery stenosis, where the venous levels of locally produced angiotensin I were particularly high. These results provide no evidence for a source of circulating angiotensin II other than blood-borne angiotensin I and illustrate the high degree of compartmentalization of angiotensin I and II production.Keywords
This publication has 30 references indexed in Scilit:
- Distribution and metabolism of angiotensin I and II in the blood vessel wall.Hypertension, 1992
- Differential regulation of angiotensin peptide levels in plasma and kidney of the rat.Hypertension, 1991
- Intrarenal de novo production of angiotensin I in subjects with renal artery stenosis.Hypertension, 1990
- Metabolism and production of angiotensin I in different vascular beds in subjects with hypertension.Hypertension, 1990
- Circulating and tissue angiotensin systems.JCI Insight, 1987
- True versus immunoreactive angiotensin II in human plasma.Hypertension, 1985
- Local generation of angiotensin II as a mechanism of regulation of peripheral vascular tone in the rat.JCI Insight, 1984
- Angiotensin I, II, and III in sheep. A model of angiotensin production and metabolism.Hypertension, 1981
- Fate of angiotensin I and II in the human pulmonary circulationThe American Journal of Cardiology, 1969
- Removal of angiotensins from the systemic circulationCanadian Journal of Physiology and Pharmacology, 1968