Circulating Omentin as a Novel Biomarker of Endothelial Dysfunction
Open Access
- 1 August 2011
- Vol. 19 (8), 1552-1559
- https://doi.org/10.1038/oby.2010.351
Abstract
Omentin is a novel soluble lectin expressed mainly in the stromal‐vascular cells from visceral adipose tissue with vasodilator effect in isolated blood vessels. To gain insight in the relationship between obesity and cardiovascular risk factors, we aimed to explore the interaction among circulating omentin, metabolic parameters, and endothelial function. Circulating omentin (enzyme‐linked immunosorbent assay) was studied in 248 white men (148 with normal glucose tolerance (NGT) and 100 with impaired glucose tolerance (IGT)). Insulin sensitivity was measured using the frequently sampled intravenous glucose tolerance test. Vascular reactivity was measured by high‐resolution ultrasound of the brachial artery. Circulating omentin concentration was significantly increased in lean compared with overweight and obese subjects (53.7 ± 16.9 vs. 45.2 ± 16.8 and vs. 40.1 ± 15.5 ng/ml, P < 0.0001). Circulating omentin concentration correlated with age, BMI, waist‐to‐hip ratio (WHR), percentage of fat mass, systolic and diastolic blood pressure, endothelium‐dependent and independent vasodilation (EDV and EIV), C‐reactive protein, and interleukin‐6 (IL‐6). In IGT subjects, circulating omentin concentration also correlated with insulin sensitivity, although this association did not remain significant after controlling for BMI. In a multiple linear regression analysis, circulating omentin concentration (P = 0.01), systolic blood pressure (P = 0.04), and BMI (P = 0.04) contributed independently to EDV after controlling for age and C‐reactive protein in IGT subjects. In NGT subjects, only circulating omentin concentration (P = 0.01) was significantly associated with EDV. In conclusion, circulating omentin concentration could be a useful marker of endothelial function.Keywords
This publication has 27 references indexed in Scilit:
- Obesity, Inflammation, and Insulin ResistanceGastroenterology, 2007
- Inflammation and metabolic disordersNature, 2006
- Adipocytokines: mediators linking adipose tissue, inflammation and immunityNature Reviews Immunology, 2006
- Clustering of Insulin Resistance With Vascular Dysfunction and Low-Grade Inflammation in Type 2 DiabetesDiabetes, 2006
- Circulating Levels of Oxidative Stress Markers and Endothelial Adhesion Molecules in Men with Abdominal ObesityJournal of Clinical Endocrinology & Metabolism, 2005
- Circulating Adiponectin and Resistin Levels in Relation to Metabolic Factors, Inflammatory Markers, and Vascular Reactivity in Diabetic Patients and Subjects at Risk for DiabetesDiabetes Care, 2004
- Obesity is associated with macrophage accumulation in adipose tissueJCI Insight, 2003
- Insulin Resistance and Chronic Cardiovascular Inflammatory SyndromeEndocrine Reviews, 2003
- C-Reactive Protein, the Metabolic Syndrome, and Risk of Incident Cardiovascular EventsCell Metabolism, 2003
- Chronic Subclinical Inflammation as Part of the Insulin Resistance SyndromeCirculation, 2000