Bone Mineral Density in Children with Non-Cystic Fibrosis Bronchiectasis
- 6 July 2007
- journal article
- Published by S. Karger AG in Respiration
- Vol. 75 (4), 432-436
- https://doi.org/10.1159/000105386
Abstract
Bronchiectasis presents as a common sequela of several chronic pulmonary diseases. Bone mineral density (BMD) is generally decreased in children with cystic fibrosis (CF). Although children with non-CF bronchiectasis have similar risk factors for osteopenia/osteoporosis, data on BMD in this group of patients are lacking. To evaluate BMD in children with non-CF bronchiectasis. In this study, we evaluated BMD of the radius and tibia in 32 children (17 girls) with non-CF bronchiectasis and in 23 healthy controls matched for age, sex and pubertal stage by quantitative ultrasound (speed of sound). Daily calcium intake and pulmonary function tests and data about steroid use were noted. Mean age was 12.5 +/- 4.6 years. Six children (18%) had moderate-to-severe lung disease (FEV(1) 0.05). However, more children with non-CF bronchiectasis had osteopenia (z-scores between -1 and -2 SD) and osteoporosis (z-score <or=2 SD) compared to the control group (62 vs. 30%, p = 0.019). There was a significant correlation between age and radius z-scores (r = -0.365, p = 0.04). There was no correlation between BMD and severity of lung illness, calcium intake or cumulative steroid doses. Osteopenia is more common in children with non-CF bronchiectasis compared to controls and the risk of osteoporosis and osteopenia increases with age.Keywords
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