A bi-faceted role of estrogen receptor β in breast cancer
- 26 March 2013
- journal article
- review article
- Published by Bioscientifica in Endocrine-Related Cancer
- Vol. 20 (3), R127-R139
- https://doi.org/10.1530/erc-12-0389
Abstract
Despite over 15 years of research, the exact role, if any, played by estrogen receptor β (ERβ) in human breast cancer remains elusive. A large body of data bothin vitroandin vivosupports its role as an antiproliferative, pro-apoptotic factor especially when co-expressed with ERα. However, there is a smaller body of data associating ERβ with growth and survival in breast cancer. In clinical studies and most often in cell culture studies, the pro-growth and pro-survival activity of ERβ occurs in ERα-negative breast cancer tissue and cells. This bi-faceted role of ERβ is discussed in this review.Keywords
This publication has 100 references indexed in Scilit:
- Generation of stable reporter breast cancer cell lines for the identification of ER subtype selective ligandsBiochemical Pharmacology, 2011
- Targeting Androgen Receptor in Estrogen Receptor-Negative Breast CancerCancer Cell, 2011
- Cracking the Estrogen Receptor's Posttranslational Code in Breast TumorsEndocrine Reviews, 2011
- An ADIOL-ERβ-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated InflammationCell, 2011
- Selectively targeting estrogen receptors for cancer treatmentAdvanced Drug Delivery Reviews, 2010
- ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-Mediated Snail Nuclear Localization: Implications for Gleason GradingCancer Cell, 2010
- Clinical Importance of Estrogen Receptor-β Evaluation in Breast Cancer Patients Treated With Adjuvant Tamoxifen TherapyJournal of Clinical Oncology, 2008
- Estrogen receptors outside the nucleus in breast cancerBreast Cancer Research and Treatment, 2007
- Involvement of estrogen receptor β in terminal differentiation of mammary gland epitheliumProceedings of the National Academy of Sciences, 2002
- Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 SitesScience, 1997