Serum IgG subclass responses of humans to inactivated and live influenza A vaccines compared to natural infections with influenza A
- 1 February 1990
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 30 (2), 92-96
- https://doi.org/10.1002/jmv.1890300203
Abstract
Studies with various viral agents have suggested that a preferential production of IgG subclasses may occur during infection, but limited information has been reported on the IgG isotypes produced during vaccination with live or killed virus preparations. The serum IgG subclass responses to influenza A infection or inoculation with live or killed influenza A vaccines were examined by an enzyme‐linked immunosorbent assay, and results were expressed using a 4‐parameter logistic model. It was observed that IgG1 was induced by both natural infections and the live virus vaccine depending on the dose given. Inactivated vaccines induced significant titres of IgG1, IgG2, and IgG3 isotypes in vaccines, again depending upon the amount of virus preparation administered.Keywords
This publication has 19 references indexed in Scilit:
- The IgG Subclass Responses Induced by Wild-type, Cold-adapted and Purified Haemagglutinin from Influenza Virus A/Queensland/6/72 in CBA/CaH MiceJournal of General Virology, 1988
- Proportions of IgG Subclasses in Antibodies Formed during Vaccination with Hepatitis B Surface AntigenScandinavian Journal of Immunology, 1986
- The Immune Response to Influenza InfectionPublished by Springer Science and Business Media LLC ,1986
- IgG Subclass Antibodies to Herpes Simplex VirusThe Journal of Infectious Diseases, 1985
- Immunoglobulin G: Functional sitesMolecular Immunology, 1985
- Antibody-Dependent Cell-Mediated Cytotoxicity Against Influenza Virus-Infected CellsThe Journal of Infectious Diseases, 1983
- Purification of influenza virus glycoproteins for the preparation and standardization of immunological potency testing reagentsJournal of Biological Standardization, 1980
- The Potential Advantages and Requirements of Live Attenuated Influenza Virus Vaccines*Australian and New Zealand Journal of Medicine, 1977
- Comparative trials of live attenuated and detergent split influenza virus vaccinesEpidemiology and Infection, 1975
- A simple procedure for removal of triton X-100 from protein samplesAnalytical Biochemistry, 1973