Hyperthyroidism and Excessive Thyrotropin Secretion
- 17 August 1972
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 287 (7), 328-333
- https://doi.org/10.1056/nejm197208172870704
Abstract
A 44-year-old woman was found to have hyperthyroidism and elevated serum thyrotropin (TSH) levels. There was no evidence of a pituitary tumor or of abnormalities in the secretion of other pituitary hormones. A modest fall in serum TSH levels and 131I uptake by the thyroid gland was observed after tri-iodothyronine administration. TSH levels increased substantially during methimazole therapy. No increases occurred after administration of thyrotropin-releasing hormone (TRH) either before or during treatment with methimazole. Administration of dexamethasone was followed by a prompt, though transient, fall in serum TSH levels. These findings suggest that the increased TSH secretion in this patient is due to excessive releasing hormone (TRH) secretion.Keywords
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