The clinical significance of splice variants and subcellular localisation of survivin in non-small cell lung cancers
Open Access
- 19 February 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 98 (6), 1109-1117
- https://doi.org/10.1038/sj.bjc.6604253
Abstract
Survivin is a member of the inhibitor of apoptosis protein family. Survivin has splice variants with different biological functions associated with tumorigenesis. We investigated 134 non-small cell lung cancers (NSCLCs) to study the clinical significance of wild-type survivin, survivin-2B, and survivin-deltaEx3. Real-time PCR analyses were performed for their gene expressions. The subcellular localisation of survivin proteins was evaluated by immunohistochemistry. The Ki-67 proliferation index and the apoptotic index were also evaluated. The survivin-deltaEx3 gene expression was significantly higher in stage II–III than in stage I (P=0.0174), and significantly correlated with the nuclear pan-survivin expression (Psurvivin-positive tumours (Psurvivin-deltaEx3-positive tumours (PP=0.0047). In contrast, the apoptotic index was significantly lower only in wild-type survivin-positive tumours (Psurvivin gene expression was associated with apoptotic inhibition and tumour proliferation. Furthermore, the survivin-deltaEx3 gene expression was strongly associated with tumour proliferation, especially in advanced stage NSCLCs. In contrast, the survivin-2B gene expression did not correlate with tumour proliferation or tumour apoptosis.This publication has 32 references indexed in Scilit:
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