Increased intima-media thickness of the common carotid artery in hypercholesterolemic children.
- 1 July 1994
- journal article
- abstracts
- Published by Ovid Technologies (Wolters Kluwer Health) in Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
- Vol. 14 (7), 1075-1079
- https://doi.org/10.1161/01.atv.14.7.1075
Abstract
Common carotid intima-media thickness was measured by B-mode ultrasound imaging in 46 children (mean age, 7.4 years) with serum cholesterol > or = 6.4 mmol/L (mean, 8.25 mmol/L) and in 48 children (mean age, 6.4 years) with serum cholesterol < 6.4 mmol/L (mean, 4.60 mmol/L). Maximum thickness was significantly higher in hypercholesterolemic children than in control children (0.50 versus 0.47 mm, P = .007). Subgroup analysis showed that only in children > 6.2 years old (the median of all the children's ages) was maximum thickness significantly higher in hypercholesterolemic children than in control children (0.51 versus 0.48 mm, P = .014). The odds ratio (OR) of common carotid intima-media thickening (maximum thickness of the far wall higher than the 95th percentile of the control group, 0.51 mm) between patients and control subjects was statistically significant both in univariate analysis (OR, 6.39; 95% confidence interval, 1.19 to 32.3; P = .025) and after age (OR, 5.96; 95% confidence interval, 1.09 to 32.4; P = .039) and sex (OR, 7.54; 95% confidence interval, 1.38 to 41.2; P = .020) were controlled for. Children > 6 years old with serum cholesterol > or = 6.4 mmol/L show increased thickness of the common carotid intima-media.Keywords
This publication has 20 references indexed in Scilit:
- Natural history of aortic and coronary atherosclerotic lesions in youth. Findings from the PDAY Study. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1993
- Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosisThe Lancet, 1992
- Will lowering population levels of serum cholesterol affect total mortality? Expectations from the honolulu heart programJournal of Clinical Epidemiology, 1992
- Should There be Intervention to Alter Serum Lipids in Children?Annual Review of Nutrition, 1991
- Extracranial carotid atherosclerosis in patients with and without transient ischemic attacks and coronary artery disease.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1990
- Coronary artery disease prevention: Cholesterol, a pediatric perspectivePreventive Medicine, 1989
- Detection and monitoring of asymptomatic atherosclerosis in clinical trialsAmerican Journal Of Medicine, 1989
- Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacinJournal of the American College of Cardiology, 1986
- Relation of Serum Lipoprotein Levels and Systolic Blood Pressure to Early AtherosclerosisNew England Journal of Medicine, 1986
- Serum total and high density lipoprotein (HDL) cholesterol concentrations in rural and urban boys from 16 countriesAtherosclerosis, 1980