THE DISTRIBUTION OF BLOOD PHOSPHORUS AFTER SUPPRESSION OF RENAL FUNCTION 1

Abstract

Rabbits and dogs were subjected to (1) intraven. injections of (a) diphtheria toxin and (b) HgCl2, and (2) bilateral ligation of the ureters, causing acute suppression of renal function. The principal changes in the blood were: (1) increased inorganic phosphates, greater in plasma than in cells; (2) increased organic acid-soluble P (ester P) in cells; (3) decreased Cl in both plasma and cells; (4) increased N.P.N. The observations further support the hypothesis, previously offered, that a reciprocal relationship exists between Cl and phosphoric esters as anions in the cells, and that an interchange between the inorganic phosphates of the plasma and the ester P of the cells may serve an important function in adjustments of the acid-base balance of the whole blood.