Biosynthesis of small proteoglycans by hepatic lipocytes in primary culture
- 4 December 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 258 (2), 233-235
- https://doi.org/10.1016/0014-5793(89)81661-8
Abstract
Chondroitin sulfate/dermatan sulfate proteoglycans were obtained from the secretions of cultured rat hepatic lipocytes. The collagen-binding small proteoglycan II represented only a minor species (less than 10%), whereas similar amounts of small proteoglycan I and of a novel collagen-binding proteoglycan with a core protein of 101 kDa were found. These results support the concept of a special role of lipocytes in the pathogenesis of liver fibrosis.Keywords
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