EXPERIMENTAL HYPOSTHENURIA 12

Abstract

Hyposthenuria, or loss of ability to excrete a concentrated urine under usual conditions, may be produced experimentally in dogs in a number of ways. These include reduction in kidney mass, uranium poisoning, ureteral obstruction, denervation, and a low protein diet. Dogs subjected to subtotal nephrec-tomy will excrete a concentrated urine under certain conditions, including increased cone, of plasma colloids, low blood pressure, and injs. of Na2SO4 after water deprivation. A urine of high sp. g. has not been obtained from dogs with tubular damage. Pituitrin leads to the excretion of a concentrated urine after renal denervation, but is without significant effect in the other groups.