Defective RNA Synthesis in Lymphocytes from Patients with Primary Agammaglobulinemia
- 3 December 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 150 (3701), 1311-1312
- https://doi.org/10.1126/science.150.3701.1311
Abstract
Addition of tetanus toxoid to sensitized lymphocytes from normal subjects and patients with "secondary" acquired agammaglobulinemia resulted in an increased incorporation of tritiated uridine into RNA and this increase was sustained for 48 to 72 hours in vitro. In contrast, the quantity of H3-uridine incorporated into the RNA of lymphocytes from patients with "primary" acquired agammaglobulinemia decreased after 48 hours of exposure to specific antigen. Lymphocytes from patients with primary agammaglobulinemia were also distinguished by their subnormal and poorly sustained response to phytohemagglutinin and to rabbit antiserum to Iymphocytes. These data suggest that the defect in primary agammaglobulinemia involves, either as a primary phenomenon or as a secondary event, an abnormality of quantitative RNA synthesis or of RNA stability in the circulating lymphocyte.This publication has 9 references indexed in Scilit:
- The pathogenesis of immunologic deficiency diseasesAmerican Journal Of Medicine, 1965
- Agammaglobulinemia: The Fundamental DefectScience, 1964
- Lymphocyte Interaction: A Potential Histocompatibility Test in vitroScience, 1964
- A RIBONUCLEIC ACID FRACTION FROM RAT LIVER WITH TEMPLATE ACTIVITYProceedings of the National Academy of Sciences of the United States of America, 1963
- ANTIBODY FORMATION INITIATED IN VITROThe Journal of Experimental Medicine, 1963
- The occurrence of rheumatoid factor and other abnormalities in families of patients with agammaglobulinemiaArthritis & Rheumatism, 1962
- The precision of ultraviolet absorption measurements in the Schmidt-Thannhauser procedure for nucleic acid estimationBiochimica et Biophysica Acta, 1962
- ANTIBODY FORMATION IN VITROThe Journal of Experimental Medicine, 1961
- MULTIPLE SERUM PROTEIN DEFICIENCIES IN CONGENITAL AND ACQUIRED AGAMMAGLOBULINEMIA 1JCI Insight, 1956