Methylphenidate and Haloperidol in Children
- 1 June 1975
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 32 (6), 790-795
- https://doi.org/10.1001/archpsyc.1975.01760240118009
Abstract
Twenty-four hyperactive or unsocialized-aggressive children participated in an exploratory double-blind crossover study comparing the cognitive effects of methylphenidate hydrochloride (0.3 mg/kg), two doses (0.25 and 0.05 mg/kg) of haloperidol, and inert placebo. Each subject received each of four drug conditions, drug order being randomized by a Latin square design. At the end of each 18-day trial period, attention, immediate recognition memory, reaction times, and seat activity were tested. While drug effects were small, methylphenidate and, to a lesser extent, the low dose of haloperidol, facilitated performance, whereas there was some suggestion that the high dose of haloperidol may have caused a slight deterioration In performance. These results are contrasted with effects on social behavior where the latter improved behavior. No differences attributable to diagnosis were found.Keywords
This publication has 20 references indexed in Scilit:
- What Is the Proper Dose of Stimulant Drugs in Children?International Journal of Mental Health, 1975
- Methylphenidate in Children—Effect of DosageAustralian & New Zealand Journal of Psychiatry, 1974
- Effects of Psychopharmacologic Agents on Learning DisordersPediatric Clinics of North America, 1973
- Stop, look and listen: The problem of sustained attention and impulse control in hyperactive and normal children.Canadian Journal of Behavioural Science / Revue canadienne des sciences du comportement, 1972
- The "One Child, One Drug" Myth of Stimulants in HyperkinesisArchives of General Psychiatry, 1971
- Methodology of Psychopharmacological Studies with the RetardedInternational Review of Research in Mental Retardation, 1971
- Haloperidol in the Treatment of Children with Severe Behaviour DisordersThe British Journal of Psychiatry, 1968
- Drug Effects on Learning in Children A Selective Review of the Past Thirty YearsThe Journal of Special Education, 1966
- Effects of chlorpromazine on learning.Psychological Bulletin, 1965
- Psychopharmacology in childhood emotional and mental disordersThe Journal of Pediatrics, 1962